A Model for the Hippo Pathway in the Drosophila Wing Disc

Mathematical Biology

06 December 15:00 - 15:45

Hans Othmer - University of Minnesota

Although significant progress has been made toward understanding morphogen-mediated patterning in development, control of the size and shape of tissues via local and global signaling is poorly understood. In particular, little is known about how cell-cell interactions are involved in the control of tissue size. The Hippo pathway in the Drosophila wing disc involves cell-cell interactions via cadherins, which lead to modulation of Yorkie, a cotranscriptional factor that affects control of the cell cycle and growth. Studies involving over- and underexpression of components of this pathway reveal conditions that lead to tissue over- or undergrowth. I will discuss a mathematical model of the Hippo pathway that can qualitatively explain these observations, made in both whole-disc mutants and mutant-clone experiments. A number of nonintuitive experimental results can be explained by subtle changes in the balances between inputs to the Hippo pathway and suggest some predictions that can be tested experimentally. Because the signal transduction and growth control pathways are highly conserved between Drosophila and mammalian systems, the model can be used as a framework to guide future experimental work on the Hippo pathway in both.
Mats Gyllenberg
University of Helsinki
Torbjörn Lundh
Chalmers/University of Gothenburg
Philip Maini
University of Oxford
Roeland Merks
Universiteit Leiden
Mathisca de Gunst
Vrije Universiteit Amsterdam


Roeland Merks


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